Y. Deng

Urine Proteomics in Methamphetamine Addicted Patients

This study compares urine proteomes of methamphetamine users, withdrawers, and healthy individuals, identifying differentially expressed proteins linked to addiction and neurotoxicity.

Poxvirus A52 is a host range factor for modified vaccinia virus Ankara (MVA) and promotes viral replication by disturbing the formation of autolysosomes

This study identifies poxvirus protein A52 as a host range factor that disrupts autolysosome formation to promote viral replication in MVA.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

Structural and Dynamical Analyses of Apo and Cap-binding eIF4E: An in silico Study

This study uses molecular dynamics simulations to analyze structural changes in eIF4E when bound to Cap and in its apo form, identifying key residues involved in conformational transitions and suggesting targets for drug design.

An AI-Driven Framework for Discovery of BACE1 Inhibitors for Alzheimer's Disease

This paper develops an AI framework to generate and optimize BACE1 inhibitors for Alzheimer's disease, identifying 14 candidates with improved binding properties.

Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)

This study uses scRNA-seq to analyze theanine metabolism in tea plant roots, revealing multicellular compartmentation of biosynthesis without high co-expression of transcription factors.

Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells

This study investigates the role of lupus-associated innate receptors in the extrafollicular development of autoreactive B cells using adoptive transfer and time-stamped analysis in a mouse model.

Evaluation of the effects of ripening-related genes on fruit metabolites and the associated regulatory mechanisms in tomato

The paper evaluates the effects of ripening-related genes on tomato fruit metabolites and identifies regulatory mechanisms, showing that HY5 mutation increases fructose and glucose levels by modulating SWEET12c expression.

ERLIN1 may be involved in DHRS1-induced Change in Lipid Droplet Morphology in HeLa Cell

This study shows DHRS1 localizes to lipid droplets in HeLa cells and alters their morphology, with ERLIN1 potentially regulating DHRS1's effect on lipid droplet size and triacylglycerol levels.

Epstein Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues

This study shows EBV infection induces tissue-resident memory T cells in mucosal lymphoid tissues in mice with humanized immune systems, but these TRMs fail to control viral loads compared to systemic effector memory T cells.

The impact of kit, environment and sampling contamination on the observed microbiome of bovine milk

This study shows that most sequence data from bovine milk samples are contaminated, with contaminants mainly from DNA kits and teat surfaces, and highlights the need for rigorous decontamination.

Vicious cycle of hemodynamic perturbation and endothelial injury in development and progression of pulmonary arterial hypertension

This study shows that hemodynamic perturbations and endothelial injury form a cycle driving pulmonary arterial hypertension, which can be reversed by unilateral lung banding.

Ras-mediated homeostatic control of front-back signaling dictates cell polarity

This study uses optogenetics to show that RasGAPs regulate cell polarity by enhancing actomyosin contractility at the back and F-actin polymerization at the front.

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

Genome analyses reveal the secondary metabolites potentially influence the geographical distribution of Fusarium pseudograminearum populations

This study analyzes genomes of Fusarium pseudograminearum strains to show that secondary metabolite synthesis genes influence their geographical distribution and toxin production.

Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2

This study uses single-cell RNA sequencing to analyze myeloid cells in PBMCs from PPASC patients and controls, identifying increased myeloid lineage cells and altered gene expression linked to fibrosis and immune suppression.

Biodegradable hyperbranched poly(amine-co-ester)-based polymeric nanoparticles for mRNA delivery

This study develops a biodegradable hyperbranched poly(amine-co-ester) nanoparticle for efficient and safe mRNA delivery, showing improved performance over existing commercial reagents.

Stanniocalcin 2 (STC2) is a potent biomarker of hepatocellular carcinoma with its expression being augmented in Nrf1α-deficient cells, but diminished in Nrf2-deficient cells

The paper identifies STC2 as a biomarker for hepatocellular carcinoma, showing its expression is increased in Nrf1α-deficient cells and decreased in Nrf2-deficient cells, with STC2 promoting tumor growth.

Modeling the role of immune cell conversion in the tumor-immune microenviroment

The paper develops an ecological model of the tumor-immune microenvironment to study immune cell conversion and its impact on tumor-immune coexistence.

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

An Acoustically Controlled Microrobot Modelled on Spirochete Bacteria

This paper introduces an acoustically driven helical microrobot that mimics spirochete motion and demonstrates switchable directionality using a double-helix structure.

Infinite Physical Monkey: Do Deep Learning Methods Really Perform Better in Conformation Generation?

The paper evaluates deep learning methods for molecular conformation generation by comparing them to a stochastic 'infinite physical monkey' approach, finding that the monkey method outperforms most DL-based methods in coverage and docking success.

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

This study develops anti-seed PNAs targeting oncomiRs 10b and 21 for GBM therapy, showing improved tumor growth inhibition and survival in mice.

CherryML: Scalable Maximum Likelihood Estimation of Phylogenetic Models

CherryML provides a scalable method for maximum likelihood estimation of phylogenetic models, achieving significant speedup in parameter estimation for molecular evolution.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson's disease

This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.

Single-cell microencapsulation improves lung retention of endothelial colony forming cells after intravascular delivery and unmasks therapeutic benefit in severe pulmonary arterial hypertension

This study shows that microencapsulation of endothelial colony forming cells (ECFCs) improves their lung retention and therapeutic efficacy in a rat model of pulmonary arterial hypertension.

Using spatio-temporal information in weather radar data to detect and track communal bird roosts

This paper develops an AI system to detect and track swallow roosts in weather radar data, improving detection performance with temporal information and reducing human effort.

Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

Digital Light Processing 3D printing for biological applications of polydimethylsiloxane-based microfluidics

The paper evaluates DLP 3D printing for PDMS microfluidics, optimizing parameters and demonstrating applications in cell viability, drug response, concentration gradients, and live-cell invasion.