Leptin protects against the development and expression of cocaine addiction-like behavior in heterogenous stock rats
L. L. G. Carrette, C. Corral, C. Crook, B. Boomhower, M. Brennan, C. Ortez, K. Shankar, S. Simpson, L. Maturin, G. de Guglielmo, L. Solberg-Woods, A. A. Palmer, O. George
This study shows that baseline blood leptin levels predict reduced vulnerability to cocaine addiction-like behavior, and exogenous leptin reduces cocaine seeking in rats.
bioRxiv · Jul 22, 2021 · PreprintPhysiology