S. Simpson

High fat low carbohydrate diet is linked to protection against CNS autoimmunity

This study links a high fat low carbohydrate diet to protection against CNS autoimmunity by showing reduced neuroinflammation and immunometabolic changes in a mouse model.

A fully phased, chromosome-scale genome of sugar beet line FC309 enables the discovery of Fusarium Yellows resistance QTL

The paper presents a chromosome-scale, haplotype-phased genome of sugar beet line FC309 and identifies a QTL for Fusarium Yellows resistance on Chromosome 3.

Nutribloods: novel synthetic lepidopteran haemolymphs for understanding insect-microbe interactions in vitro

The paper introduces synthetic haemolymphs (nutribloods) to study how nutrient profiles affect microbial growth in insect-pathogen interactions.

Sleep selectively and durably enhances real-world sequence memory

The paper shows sleep selectively enhances sequence memory for real-world experiences over time, with effects growing up to one year post-encoding.

Fungal infection alters collective nutritional intake of ant colonies

This study shows that fungal infection in ants changes their dietary choices to support immune responses, even though the diet is harmful in the long term.

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

This study characterizes the heterogeneous and adaptive cytoprotective responses of C. albicans to antifungal compounds using single-cell transcriptomics.

Individual differences in members of Actinobacteria, Bacteroidetes, and Firmicutes is associated with resistance or vulnerability to addiction-like behaviors in heterogeneous stock rats

The paper identifies microbiome composition and metabolic pathways associated with resistance or vulnerability to addiction-like behaviors in rats using a large cohort and extended cocaine self-administration.

Leptin protects against the development and expression of cocaine addiction-like behavior in heterogenous stock rats

This study shows that baseline blood leptin levels predict reduced vulnerability to cocaine addiction-like behavior, and exogenous leptin reduces cocaine seeking in rats.

An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys

This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.

A deep learning approach to capture the essence of Candida albicans morphologies

This paper develops a deep learning system called Candescence to detect and classify C. albicans morphologies from microscopy images using a curriculum-based learning strategy and GANs.

Rapid blood acid-base regulation by European sea bass (Dicentrarchus labrax) in response to sudden exposure to high environmental CO2

European sea bass rapidly regulate blood and red cell pH within 2 hours and 40 minutes, respectively, protecting O2 transport capacity via enhanced gill acid excretion.

A metagenomic-based stufy of two sites from the Barbadian reef system

The paper analyzes the microbiome of two Barbadian coral reef sites using metagenomic sequencing to compare microbial community composition in relation to environmental factors.

Dietary protein increases T cell independent sIgA production through changes in gut microbiota-derived extracellular vesicles

The paper shows dietary protein increases sIgA via gut microbiota-derived extracellular vesicles, independent of T cell pathways or microbiota composition.

INSULIN-LIKE PEPTIDES REGULATE FEEDING PREFERENCE AND METABOLISM IN DROSOPHILA

This study identifies distinct roles of Drosophila insulin-like peptides in regulating metabolism, appetite, and carbohydrate storage in fruit flies.