C. Coscolin

The mobility of the cap domain is essential for the substrate promiscuity of a family IV esterase from sorghum rhizosphere microbiome

This paper identifies and characterizes a novel esterase from the Sorghum bicolor rhizosphere microbiome, revealing that its cap domain mobility enables broad substrate promiscuity despite a narrow catalytic tunnel.

Promiscuous esterases counterintuitively are less flexible than specific ones

The paper shows that promiscuous esterases are less flexible and more thermostable than specific ones, challenging the common assumption about enzyme flexibility and promiscuity.