A high-content screen identified ingenol-3-angelate as an enhancer of B7-H3-CAR T cell activity by increasing B7-H3 protein expression on the target cell surface via protein kinase C alpha activation
H. W. Lee, C. O'Reilly, A. N. Beckett, D. G. Currier, T. Chen, C. DeRenzo
The paper identifies ingenol-3-angelate as a drug that enhances B7-H3-CAR T cell activity by increasing B7-H3 protein expression on target cells through protein kinase C alpha activation.
bioRxiv · May 26, 2023 · PreprintCancer Biology