Cancer BiologybioRxivPreprint
A high-content screen identified ingenol-3-angelate as an enhancer of B7-H3-CAR T cell activity by increasing B7-H3 protein expression on the target cell surface via protein kinase C alpha activation
H. W. Lee, C. O'Reilly, A. N. Beckett…·C. DeRenzo
The paper identifies ingenol-3-angelate as a drug that enhances B7-H3-CAR T cell activity by increasing B7-H3 protein expression on target cells through protein kinase C alpha activation.
DOI 10.1101/2023.05.26.542130