T. Chen

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

This study uses a protein language model to discover new phosphorus-cycling protein families in deep-sea cold seep sediments, revealing novel microbial processes and ecological roles.

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Alarm functions of PD-1+ brain resident memory T cells

This study shows brain-resident memory T cells (TRM) can rapidly remodel the CNS immune landscape through activation of multiple immune cells, and PD-1 inhibits granzyme B but not alarm responses.

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

Super-resolution going viral: T4 virus particles as perfect nature-designed 3D-Bio-NanoRulers

The paper introduces bacteriophage T4 as a 3D bio-ruler for super-resolution imaging, demonstrating its structure and potential as a benchmark.

Feather degradation in Stenotrophomonas maltophilia relies on conversion and internalization of keratin monomer

This study shows Stenotrophomonas maltophilia degrades feathers by converting them into keratin monomers, which enter cells to trigger keratinase activity and complete hydrolysis.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Unveiling Tryptophan Dynamics and Functions Across Model Organisms via Quantitative Imaging

This study uses GRIT to measure tryptophan dynamics across species and scales, revealing links between tryptophan metabolism, inflammation, and behavior.

Science Education for the Youth (SEFTY): A Neuroscience Outreach Program for High School Students in Southern Nevada During the COVID-19 Pandemic

The SEFTY program provided neuroscience-based experiential learning to high school students during the pandemic, improving science proficiency by 20.3%.

Observation of E-cadherin Adherens Junctions Variation with Metal-induced Energy Transfer Imaging/Spectroscopy

This study uses metal-induced energy transfer imaging to analyze E-cadherin junction dynamics and identifies a transient X-dimer state and its impact on membrane displacement.

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.

Multifrequency control of Faraday wave bioassembly for constructing multiscale hPSC-derived neuronal networks

This paper introduces a multifrequency Faraday wave bioassembly technique to create multiscale neuronal networks from hPSCs, demonstrating spontaneous neuroelectrical activity.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

Proteomic Features of Adolescents and Young Adults with Soft Tissue Tumours

This study compares proteomic profiles of adolescents and young adults with soft tissue tumours to older adults, identifying age-specific molecular features and potential therapeutic targets.

Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

Targeting phosphoRab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson's Disease

This paper demonstrates that constrained peptides mimicking phosphorylated Rab8 can block RILPL interactions and restore ciliogenesis and centrosomal cohesion defects in cells with mutant LRRK2.

Vegetation of Chamaecyparis montane cloud forest in Lalashan Forest Dynamics Plot

The paper establishes and describes a 1-ha forest dynamics plot in Taiwan's Chamaecyparis montane cloud forest, analyzing vegetation-environment relationships through census data and environmental measurements.

Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis

This study shows that warm temperatures suppress systemic acquired resistance in plants by reducing N-hydroxypipecolic acid biosynthesis, affecting both local and systemic immunity.

Structural and molecular basis of choline uptake into the brain by FLVCR2

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

The Discovery and Characterization of 1,4-Dihydroxy-2-naphthoic Acid Prenyltransferase Involved in the Biosynthesis of Anthraquinones in Rubia cordifolia

This study identifies and characterizes RcDT1, a prenyltransferase involved in anthraquinone biosynthesis in Rubia cordifolia, and shows its evolutionary origin from the ubiquinone pathway.

Glioma-neuronal circuit remodeling induces regional immunosuppression

This study shows that glioma-induced neuronal circuit remodeling creates regional immunosuppression in glioblastomas by altering tumor-associated macrophages and T-cell infiltration.

Actin-Driven Nanotopography Promotes Stable Integrin Adhesion Formation in Developing Tissue

The paper shows that actin-driven membrane protrusions create nanotopographies that enable stable integrin adhesion in Drosophila muscle attachment sites.

H2O2 sulfenylates CHE linking local infection to establishment of systemic acquired resistance

The paper identifies H2O2-mediated sulfenylation of CHE as a mechanism for systemic acquired resistance in plants.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

Trafficking Machinery is Rapidly Primed to Facilitate Polarised IL-6 Secretion in Dendritic Cells

This study shows that LPS rapidly primes trafficking machinery in dendritic cells to enhance polarized IL-6 secretion through phosphorylation of VAMP3.