H. W. Lee

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

The paper identifies ingenol-3-angelate as a drug that enhances B7-H3-CAR T cell activity by increasing B7-H3 protein expression on target cells through protein kinase C alpha activation.

This study shows that Beclin1-deficient adipocytes promote tumor progression via YAP/TAZ signaling, and inhibiting this pathway reduces tumor growth in mice.

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

This study investigates how remdesivir's antiviral activity varies across RNA viruses by analyzing its incorporation and inhibition mechanisms in different polymerases.

This paper shows that 6',6'-difluoro-aristeromycin inhibits MERS-CoV replication but is cytotoxic and needs improvement for broader antiviral use.

The paper compares anatomical organization and modularity in the skulls of archosaurs, finding differences between birds and non-avian dinosaurs, and ontogenetic changes in alligators and birds.