Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis
W. H. Chin, C. Kett, O. Cooper, D. Müseler, Y. Zhang, R. S. Bamert, R. Patwa, L. C. Woods, C. Devendran, J. Tiralongo, T. Lithgow, M. J. McDonald, A. Neild, J. J. Barr
This study shows that bacteriophages adapt to the mammalian gut mucosa through mutations and recombination, gaining a fitness advantage by altering their binding to mucin glycans.
bioRxiv · May 11, 2021 · PreprintMicrobiology