T. Lithgow

A new model of endotracheal tube biofilm identifies combinations of matrix-degrading enzymes and antimicrobials able to eradicate biofilms of pathogens that cause ventilator-associated pneumonia

This paper introduces an in vitro model of endotracheal tube biofilms that demonstrates the effectiveness of combining matrix-degrading enzymes with antimicrobials to eradicate pathogens causing ventilator-associated pneumonia.

Treatment history shapes the evolution of complex carbapenem-resistant phenotypes in Klebsiella spp.

This study shows that treatment history influences the evolution of carbapenem resistance in Klebsiella by shaping the genetic loci involved and their fitness costs.

Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity

The paper identifies an additional signal in bacterial outer membrane proteins that enhances assembly efficiency and maintains membrane integrity through interaction with BamD.

Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis

This study shows that bacteriophages adapt to the mammalian gut mucosa through mutations and recombination, gaining a fitness advantage by altering their binding to mucin glycans.

The component parts of bacteriophage virions accurately defined by a machine-learning approach built on evolutionary features.

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

Periplasm homeostatic regulation maintains spatial constraints essential for cell envelope processes and cell viability

This study shows that elongated Lpp in E. coli counteracts periplasmic enlargement through homeostatic mechanisms involving Lpp tilting and abundance reduction, impacting cell envelope processes and viability.

BonA from Acinetobacter baumannii forms a divisome-localized decamer that supports outer envelope function

This study identifies BonA as an outer membrane protein in Acinetobacter baumannii that forms a transient decamer, supports outer envelope function, and is involved in cell division and motility.

Isolation and chacterisation of Klebsiella phages for phage therapy

This study isolates and characterizes 30 novel Klebsiella phages, finding that lytic phages are most suitable for therapy but single phages are insufficient due to rapid resistance development.

The crystal structure of the TonB-dependent transporter YncD reveals a positively charged substrate binding site.

The paper determines the crystal structure of YncD, a TonB-dependent transporter, revealing a positively charged substrate-binding site, but shows it does not contribute to iron transport in E. coli.

The structure of the iron-catecholate transporter Fiu suggests substrate import occurs via a 2-step mechanism

The paper determines the structure of the Fiu transporter and reveals a 2-step mechanism for substrate import, which has implications for antibiotic development.