Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated Viruses
V. C. Yin, P. Devine, J. Saunders, A. Hines, S. Shepherd, M. Dembek, C. Dobson, J. Snijder, N. Bond, A. J. R. Heck
The paper characterizes recombinant adeno-associated viruses (rAAVs) using native mass spectrometry, revealing spectral interferences caused by heterogeneity and charging behavior.
bioRxiv · Aug 27, 2022 · PreprintBiochemistry