Author

J. Saunders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. A. Hariri· 1 shared A. Agrawal· 1 shared A. Ballabio· 1 shared A. Hines· 1 shared A. J. R. Heck· 1 shared A. Jha· 1 shared A. Kossenkov· 1 shared A. M. Damry· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperBioengineering

A. A. Hariri

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

V. Vongsouthi, R. Georgelin, D. Matthews, J. Saunders, B. M. Lee, J. Ton, A. M. Damry, R. Frkic, M. A. Spence, C. J. Jackson

This study uses ancestral sequence reconstruction to explore PET-degrading cutinase sequence space, revealing diverse evolutionary pathways and the effectiveness of LASE in mapping fitness landscapes.

bioRxiv · Apr 25, 2024Biochemistry

An Antibody-Based Molecular Switch for Continuous Biosensing

I. A. P. Thompson, J. Saunders, L. Zheng, A. A. Hariri, N. Maganzini, A. P. Cartwright, J. Pan, M. Eisenstein, H. T. Soh

This paper introduces an antibody-based molecular switch for continuous biosensing of biomarkers without sample preparation, demonstrating real-time detection of digoxigenin and cortisol with adjustable sensitivity.

bioRxiv · Mar 7, 2023 · PreprintBioengineering

Cellular protection from H2O2 toxicity by Fv-Hsp70 and mutants of Fv-Hsp70. Protection via catalase and gamma-glutamyl cysteine synthase.

C. Hino, G. Chan, G. Jordaan, S. S. Chang, J. Saunders, M. T. Bashir, J. E. Hansen, J. Gera, R. H. Weisbart, R. N. Nishimura

This study shows Fv-Hsp70 and its mutants protect SH-SY5Y cells from H2O2 toxicity through a protein-binding domain, and this protection involves catalase and gamma-glutamylcysteine synthase.

bioRxiv · Feb 22, 2023 · PreprintCell Biology

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

K. Sikder, E. Phillips, Z. Zhong, N. Wang, J. Saunders, D. Mothy, A. Kossenkov, T. Schneider, Z. Nichtova, G. Csordas, K. B. Margulies, J. C. Choi

This study identifies perinuclear stress responses from nuclear envelope deterioration as contributors to LMNA cardiomyopathy using a mouse model and translatome profiling.

bioRxiv · Feb 14, 2023 · PreprintCell Biology

A receptor tyrosine kinase regulated by the transcription factor VAB-3/PAX6 pairs with a pseudokinase to trigger immune signalling upon oomycete recognition in C. elegans

F. Drury, M. Grover, M. Hintze, J. Saunders, M. K. Fasseas, C. Constantinou, M. Barkoulas

This study identifies receptor tyrosine kinase OLD-1 and pseudokinase FLOR-1 as key components of oomycete recognition in C. elegans, regulated by VAB-3/PAX-6 and forming a genetic cluster with chil genes.

bioRxiv · Dec 15, 2022 · PreprintImmunology

Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated Viruses

V. C. Yin, P. Devine, J. Saunders, A. Hines, S. Shepherd, M. Dembek, C. Dobson, J. Snijder, N. Bond, A. J. R. Heck

The paper characterizes recombinant adeno-associated viruses (rAAVs) using native mass spectrometry, revealing spectral interferences caused by heterogeneity and charging behavior.

bioRxiv · Aug 27, 2022 · PreprintBiochemistry

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

J. Goodwin, W. G. Walkup, K. Hooper, T. Li, C. Kishi-Itakura, A. Ng, T. Lehmberg, A. Jha, S. Kommineni, K. Fletcher, J. Garcia-Fortanet, Y. Fan, Q. Tang, M. Wei, A. Agrawal, , L. O. Murphy

bioRxiv · Feb 22, 2021Cell Biology