A novel sustained release therapy of combined VEGF and TNF-alpha inhibitors leads to pan-ocular protection for months after severe ocular trauma.
C. Zhou, F. Lei, P.-C. Hui, N. Wolkow, C. Dohlman, D. G. Vavvas, J. Chodosh, E. I. Paschalis
This paper develops a thermosensitive hydrogel DDS for sustained delivery of anti-TNF and anti-VEGF drugs, showing long-term ocular protection after corneal injury.
bioRxiv · Mar 14, 2023 · PreprintPathology