C. Zhou

Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.

Microbiota and metabolic adaptation shape Staphylococcus aureus virulence and antimicrobial resistance during intestinal colonization

This study shows that gut microbiota depletion allows MRSA to adapt through genetic changes that enhance colonization fitness but reduce antimicrobial resistance and virulence.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Prenatal Exposure to Environmentally Relevant Low Dosage Dibutyl Phthalate Reduces Placental Efficiency in CD-1 Mice

This study shows that low-dose prenatal DBP exposure reduces placental efficiency in female fetuses but not males in CD-1 mice.

Imaging and quantification of prostate cancer-associated bone by polarization-sensitive optical coherence tomography

This study uses PS-OCT to differentiate bone tissue types in prostate cancer metastases by analyzing collagen organization and quantifying structural features.

UXS1 regulates UDP-GlcA levels to support growth of UGDH-high cancer cells

The paper identifies UXS1 as a selectively essential gene in UGDH-high cancer cells, showing it regulates UDP-GlcA levels to prevent toxicity and highlights it as a therapeutic target.

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA

This study shows bacterial ExoIII can cleave single-stranded DNA (ssDNA) via exonuclease and endonuclease activities, revealing new enzymatic functions and implications for biosensor design.

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclampsia-like Phenotypes: Transcriptome, Phosphoproteome, and Cell Functions

This study shows that an endogenous AhR ligand induces PE-like phenotypes by altering transcriptome, phosphoproteome, and vascular functions in pregnant rats and HUVECs.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Xanthomonas euvesicatoria effector XeAvrRxo1 triggers a Rxo1-mediated defense response in Nicotiana benthamiana and its chaperone Xe4429 functions as an antitoxin, an expression repressor, and an enhancer of XeAvrRxo1 secretion

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry

This study identifies VM-competent non-neuroendocrine cells in SCLC that support vessel formation and tumor growth through integrin β1-dependent ECM remodeling.

Exploring Degradation of Intrinsically Disordered Protein YAP induced by PROTACs

This study develops PROTACs to degrade YAP, showing effective tumor suppression in cancer cell lines and xenograft models.

Prevotella copri-related effects of a therapeutic food for malnutrition

The paper investigates the role of Prevotella copri in mediating the metabolic effects of a therapeutic food for malnutrition using gnotobiotic mouse models and multi-omics analyses.

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

MicroRNA-29 Differentially Mediates Preeclampsia-Dysregulated Cellular Responses to Cytokines in Female and Male Fetal Endothelial Cells

This study identifies miR-29a/c-3p dysregulation in PE as sex-specific modulator of cytokine responses in fetal endothelial cells, with distinct effects on monolayer integrity and proliferation.

A novel sustained release therapy of combined VEGF and TNF-alpha inhibitors leads to pan-ocular protection for months after severe ocular trauma.

This paper develops a thermosensitive hydrogel DDS for sustained delivery of anti-TNF and anti-VEGF drugs, showing long-term ocular protection after corneal injury.

Benchmarking robust spatial transcriptomics approaches to capture the molecular landscape and pathological architecture of archived cancer tissues

This study benchmarks spatial transcriptomics methods on archived FFPE cancer tissues, revealing molecular landscapes and pathological features, including non-coding RNA expression.

Three-dimensional imaging and quantification of mouse ovarian follicles via optical coherence tomography

This study uses SD-OCT to identify and quantify ovarian follicles in mice, showing agreement with histology and improved image contrast for follicle analysis.

A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

This paper develops a patterned human heart tube organoid model using pluripotent stem cell self-assembly, showing anterior-posterior patterning and multiple cardiac cell types.

The effects of pks+ Escherichia coli and bile acid in colorectal tumorigenesis among people with cholelithiasis or cholecystectomy.

This study investigates the association between pks+ Escherichia coli, bile acid metabolism, and colorectal neoplasia in patients with cholelithiasis or cholecystectomy, finding enrichment of pks+ E. coli and links to colorectal adenoma and cancer.

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

The prophylactic value of TNF-alpha inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma

This study evaluates the toxicity and efficacy of TNF-alpha inhibitors adalimumab and infliximab in preventing retinal cell apoptosis and optic nerve axon loss in rabbits after corneal injury.

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.