F. Lei

Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

Genetic purging of strongly deleterious mutations underlies black-necked crane's unusual escape from an extinction vortex

This study shows black-necked cranes rapidly recovered from a population bottleneck through genetic purging of deleterious mutations, escaping an extinction vortex.

An Evaluation of the Tumor Microenvironment through CALR,IL1R1,IFNB1,and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

This study evaluates ICD-related genes in bladder cancer to assess prognosis and immunotherapy response, finding higher ICD expression correlates with better survival and response to PD1-targeted therapy.

Introgression underlies phylogenetic uncertainty but not parallel plumage evolution in a recent songbird radiation

The paper investigates phylogenetic uncertainty and parallel plumage evolution in wagtails using whole genome data, finding introgression causes gene tree discordance but not parallel plumage evolution.

A novel sustained release therapy of combined VEGF and TNF-alpha inhibitors leads to pan-ocular protection for months after severe ocular trauma.

This paper develops a thermosensitive hydrogel DDS for sustained delivery of anti-TNF and anti-VEGF drugs, showing long-term ocular protection after corneal injury.

Gene expression plasticity followed by genetic change during colonization a high-elevation environment

The paper quantifies gene expression plasticity and genetic change in Eurasian Tree Sparrows during high-elevation colonization, showing plasticity is often reversed or reinforced through selection.

The prophylactic value of TNF-alpha inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma

This study evaluates the toxicity and efficacy of TNF-alpha inhibitors adalimumab and infliximab in preventing retinal cell apoptosis and optic nerve axon loss in rabbits after corneal injury.

Species-specific traits mediate avian demographic responses under past climate change

The paper reconstructs demographic histories of 263 bird species using whole-genome sequences and identifies trait networks influencing population size changes in response to climate warming and cooling.

CSF1R inhibition by small molecule affects T-helper cell differentiation independently of microglia depletion

This study shows that CSF1R inhibition affects T-helper cell differentiation in CD4+ cells, independent of microglia depletion.

Opposing roles of blood-borne monocytes and tissue-resident macrophages in limbal stem cell damage after ocular injury

This study shows that limbal stem cell damage after ocular injury is mediated by peripheral monocytes rather than direct chemical injury, with tissue-resident macrophages providing protection.

New distributional opportunities with niche innovation in Eurasian snowfinches

This study identifies a niche evolution event in Montifringilla nivalis that enabled its broad geographic distribution and altered the distributional potential of the snowfinch lineage.

Infection risk and extensive parental care govern the molecular evolution of Toll-like receptors in birds.

This study examines the molecular evolution of Toll-like receptor genes in birds, finding that positive selection is linked to migration, parental care, and body size.

Permanent neuroglial remodeling of the retina following infiltration of CSF1R-inhibition resistant peripheral monocytes.

This study shows that peripheral monocytes infiltrate the retina after injury, engraft permanently, resist CSF1R inhibition, and contribute to long-term pro-inflammatory neuroglial remodeling.