Splenic follicular B cells promote adverse cardiac remodeling after myocardial infarction via MHC II-dependent antigen presentation.
O. V. Ebenebe, J. P. Lovell, C. Duque, Y. Song, S. Rousseau, K. S. Keole, S. Sedighi, A. Bhalodia, K. Bermea, C. D. Cohen, M. R. Mugnier, D. B. Foster, S. Krummey, S. Sidoli, L. Adamo
This study shows splenic follicular B cells worsen heart failure after MI by presenting cardiac antigens via MHC II, promoting adverse cardiac remodeling.
bioRxiv · May 8, 2024 · PreprintImmunology