J. So

DNA damage drives antigen diversification through mosaic VSG formation in Trypanosoma brucei

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.

Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patients

This study identifies immune-related gene expression changes in asymptomatic Chagas cardiomyopathy patients, suggesting unique immune mechanisms in early disease progression.

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

VRK1 is required in VRK2-methylated cancers of the nervous system

The paper identifies VRK1 as a synthetic lethal target in VRK2-methylated nervous system cancers through CRISPR screens and functional studies.

Inhibition of pyrimidine biosynthesis targets protein translation in AML.

This study shows that DHODH inhibitors block protein translation in AML by reducing YY1 and enhance AML treatment while sparing normal blood cells.

VSGs expressed during natural T. b. gambiense infection exhibit extensive sequence divergence and a subspecies-specific expression bias

This study identifies VSG expression patterns in T. b. gambiense infections, revealing subspecies-specific biases and sequence divergence.

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

Effect of cholesterol on permeability of carbon dioxide across lipid membranes

The paper measures CO2 permeability in POPC-cholesterol lipid membranes using a microfluidic assay and finds cholesterol reduces permeability by an order of magnitude.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.