S. Sidoli

Histones are exosome membrane proteins regulated by cell stress

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

This study shows that H3K36M mutations in HNSCC create a therapeutic window by altering H3K27me3 levels, making tumors sensitive to PARP1/2 inhibitors or their combination with H3K27me3-upregulating agents.

Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model

This study shows that 3D liver spheroids can model chromatin dynamics and reversible histone acetylation, with cells recovering their original transcriptome and proteome after histone deacetylase inhibitor treatment.

Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation

The paper uses locus-specific proteomics to identify proteins associated with the V region chromatin in SHM and validates their function using a Dot1L inhibitor.

mTORC2 couples fasting to mitochondrial fission

The paper shows that mTORC2 activation during fasting promotes mitochondrial fission and respiratory function through NDRG1 phosphorylation and interaction with Cdc42.

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

Functional Contribution of Cancer-Associated Fibroblasts in Glioblastoma

This study identifies and characterizes cancer-associated fibroblasts (CAFs) in glioblastoma using single-cell RNA sequencing and spatial transcriptomics, revealing their functional roles in tumor progression and microenvironment interactions.

PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER-stress reduction

This paper develops first-in-class PROTACs that selectively degrade cytosolic sEH, reducing ER stress more effectively than sEH inhibitors.

Epigenetic dysregulation from chromosomal transit in micronuclei

This study shows that chromosomal transit through micronuclei causes epigenetic dysregulation in cancer cells, leading to long-term chromatin accessibility abnormalities.

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during Toxoplasma gondii infection

This study identifies GRA64, a Toxoplasma gondii dense granule protein that interacts with host ESCRT proteins, and shows its role in intracystic vesicle formation during chronic infection.

Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies

This study shows that South American yellow fever virus strains are less susceptible to vaccine-induced antibodies due to genetic changes in the glycoprotein E.

Type I PRMTs and PRMT5 Inversely Regulate Post-Transcriptional Intron Detention

This study shows PRMTs inversely regulate intron retention post-transcriptionally through arginine methylation of Sm and CHTOP proteins.

Cytoplasmic labile iron accumulates in aging stem cells perturbing a key rheostat for identity control

This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.

A dynamic and combinatorial histone code drives malaria parasite asexual and sexual development

This study identifies novel histone PTMs and their combinatorial interactions in Plasmodium falciparum, revealing their role in regulating gene expression during asexual and sexual development.

VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms

This study shows VAL genes regulate vegetative phase change through both miR156-dependent and independent mechanisms in plants.

Toxoplasma gondii PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector export

This study identifies TgPPM3C, a secreted phosphatase in Toxoplasma gondii, and shows it regulates effector export and host c-Myc induction by modulating phosphorylation of proteins like GRA16.

PAX8 orchestrates an angiogenic program through interaction with SOX17

This study identifies SOX17 as a PAX8-interacting partner and shows their role in regulating tumor angiogenesis in ovarian cancer, suggesting a new therapeutic target.

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

One-shot analysis of translated mammalian lncRNAs with AHARIBO

The paper introduces AHARIBO, a method to identify ribosome-associated and peptide-producing lncRNAs, and applies it to mouse embryonic stem cells during neuronal differentiation to distinguish lncRNAs as ribosome sponges or micropeptide encoders.