Author

M. R. Mugnier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Chagas working group· 2 shared J. M. Hakim· 2 shared J. So· 2 shared R. H. Gilman· 2 shared A. Beaver· 1 shared A. Luigi· 1 shared A. Sayeed· 1 shared A. Waltmann· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

Chagas working group

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivOct 3, 2023

Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patients

C. Duque, J. So, Y. E. Castro-Sesquen…·Chagas working group

This study identifies immune-related gene expression changes in asymptomatic Chagas cardiomyopathy patients, suggesting unique immune mechanisms in early disease progression.

DOI 10.1016/j.lana.2025.101090

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivNov 16, 2022

Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi and informs the dynamics of parasite transmission

J. M. Hakim, A. Waltmann, F. Tinajeros…·Chagas working group

The paper uses amplicon sequencing to analyze parasite strain diversity in mothers and infants infected with Trypanosoma cruzi, finding multiple strains in some individuals and increased diversity in infants post-birth.

DOI 10.1093/infdis/jiad125

metagenomicsexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivJun 27, 2022

Extravascular spaces are the primary reservoir of antigenic diversity in Trypanosoma brucei infection

A. Beaver, Z. Keneskhanova, R. O. Cosentino…·M. R. Mugnier

The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.

DOI 10.1038/s41586-024-08151-z

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivSep 9, 2021

VSGs expressed during natural T. b. gambiense infection exhibit extensive sequence divergence and a subspecies-specific expression bias

J. So, S. Sudlow, A. Sayeed…·M. R. Mugnier

This study identifies VSG expression patterns in T. b. gambiense infections, revealing subspecies-specific biases and sequence divergence.

DOI 10.1128/mbio.02553-22

humanmouse

𝕏 PostBluesky