Monitoring the 5`UTR landscape reveals 5`terminal oligopyrimidine (TOP) motif switches to drive translational efficiencies
R. Weber, U. Ghoshdastider, D. Spies, C. Dure, F. Valdivia-Francia, M. Forny, M. Ormiston, P. F. Renz, D. Taborsky, M. Yigit, H. Yamahachi, A. Sendoel
The paper uses long-read sequencing to analyze 5'UTR isoforms in epidermal stem cells and squamous cell carcinomas, showing TOP motif switches affect translational efficiency.
bioRxiv · Jul 2, 2021 · PreprintCancer Biology