Author

C. Dureja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:C. elegans· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Deshpande· 2 shared A. O. Olaitan· 2 shared J. G. Hurdle· 2 shared J. T. Rutherford· 2 shared K. E. Hevener· 2 shared A. J. Gonzales-Luna· 1 shared A. M. McKelvey· 1 shared C. S. Pepperell· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. Deshpande

Mutual co-authors in cluster

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3 papers

Recent·Most cited

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

C. Dureja, J. T. Rutherford, F. B. A. Pavel, K. Norseeda, I. Prah, D. Sun, K. E. Hevener, J. G. Hurdle

This study evaluates the in vivo efficacy of phenylimidazole 296 against C. difficile by targeting CdFabK, showing it retains microbiome stability better than vancomycin and fidaxomicin.

bioRxiv · Sep 22, 2023 · PreprintMicrobiology

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

A. O. Olaitan, C. Dureja, M. Youngblom, M. A. Topf, W.-J. Shen, A. J. Gonzales-Luna, A. Deshpande, K. E. Hevener, J. Freeman, M. H. Wilcox, K. L. Palmer, K. W. Garey, C. S. Pepperell, J. G. Hurdle

This study identifies a mutation in C. difficile that causes metronidazole resistance and links it to fluoroquinolone resistance, contributing to the spread of drug-resistant strains.

bioRxiv · Sep 23, 2022Microbiology

The Ferrous Iron Transporter FeoB1 is Essential for Clostridioides difficile Toxin Production and Pathogenesis in Mice

A. Deshpande, C. Dureja, A. M. McKelvey, W. Zhao, J. T. Rutherford, A. O. Olaitan, J. Hurdle

This study shows that FeoB1 is critical for C. difficile toxin production and virulence, suggesting it as a therapeutic target for CDI.

bioRxiv · Mar 3, 2022 · PreprintMicrobiology