W. Zhao

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Coaching ribosome biogenesis from the nuclear periphery

This study shows that nuclear invaginations regulate ribosome biogenesis by contacting nucleoli, with high curvature increasing ribosome production and low curvature reducing it.

Directed Micro-Ecology Application System: On-site One-step Fermentation Facilitating Microbial Application through Theoretical and Equipment Innovation

The paper introduces a directed micro-ecology system with an intelligent fermentor that enhances microbial stability and effectiveness across multiple applications.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway

The paper identifies IFI207 as a rapidly evolving protein that controls retroviral replication through the STING pathway, highlighting its role in host-pathogen co-evolution.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease

The paper analyzes meta-transcriptomic data from companion animals to identify microbial communities and assess zoonotic risks.

Pure Nano Genesis: Pioneering Universal Aqueous Nanostrategies from Pure Molecules to Revolutionise Diverse Applications

This paper introduces a novel method for creating stable aqueous nanoparticles from pure conjugated molecules, demonstrating their efficacy in treating various diseases in vivo.

Hepatitis E virus infection upregulates ING5 expression in vitro and vivo

This study shows that HEV infection increases ING5 expression in both animal models and human cells, suggesting a potential role in HEV pathogenesis.

In Vitro Efficacy of Next Generation Dihydrotriazines and Biguanides Against Babesiosis and Malaria Parasites

This study screens dihydrotriazines and biguanides against Babesia and Plasmodium parasites to identify effective antifolates with broad-spectrum activity and high therapeutic indices.

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Kaempferol exerts anti-inflammatory effects by accelerating Treg development via AhR-mediated and PU.1/IRF4-dependent transactivation of the Aldh1a2/RALDH2 gene in dendritic cells

This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

This study uses a Transformer model to design novel succinate dehydrogenase inhibitors against agricultural fungi, resulting in potent antifungal compounds through virtual screening and optimization.

Hist2Cell: Deciphering Fine-grained Cellular Architectures from Histology Images

Hist2Cell predicts fine-grained transcriptional cell types from histology images with high accuracy, enabling cellular mapping and cancer prognosis.

50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

Effects of different feeding methods on serum biochemical indexes, metabolic indexes, immune indexes, and intestinal microorganisms of Nanjiang yellow goats

This study examines how different feeding methods affect serum biochemical, immune, and metabolic indicators and intestinal microbiota in Nanjiang Yellow goats, finding significant differences in metabolites, immune factors, and microbial composition.

Functional consequences of reductive protein evolution in a minimal eukaryotic genome

This study examines how protein reduction in microsporidia affects function, showing that most proteins cannot complement yeast orthologs and are more reduced in length.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

Electron-bifurcation and fluoride efflux systems in Acetobacterium spp. drive defluorination of perfluorinated unsaturated carboxylic acids

This study identifies electron-bifurcation and fluoride efflux systems in Acetobacterium spp. that enable reductive defluorination of PFAS, supported by biochemical and structural evidence.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

Multifrequency control of Faraday wave bioassembly for constructing multiscale hPSC-derived neuronal networks

This paper introduces a multifrequency Faraday wave bioassembly technique to create multiscale neuronal networks from hPSCs, demonstrating spontaneous neuroelectrical activity.

Cellular COPI components promote geminivirus infections by facilitating the chloroplast localization of viral C4/AC4 proteins

This study identifies the COPI pathway's role in transporting geminiviral C4/AC4 proteins to chloroplasts, facilitating infection and suggesting COPI manipulation as an antiviral strategy.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein

This study uses CRISPR/Cas9 RNP to edit regulatory DNA elements in human islet cells, revealing their role in diabetes risk and β cell function.

Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

This study uses lineage tracing and scRNA-seq to analyze drug resistance in glioblastoma cells treated with KIF11 inhibitor ispinesib, finding resistance-associated phenotypic changes and potential drug combinations.