D. Sun

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity Through B Cell Antigen Presentation

This study develops a neoantigen vaccine using SARS-CoV-2 B cell epitopes to enhance CD4/CD8 T cell immunity through B cell antigen presentation, showing improved efficacy in multiple cancer models.

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

This paper engineers Escherichia coli Nissle 1917 to block antibiotic resistance gene transfer using a type I CRISPR-Cas system, showing efficacy in vitro and in zebrafish.

Reconstitution of the uterine immune milieu after transplantation

This study shows that the uterine immune system can fully reconstitute after uterus transplantation or hematopoietic stem cell transplantation, despite immunosuppressive drugs.

Activity of DNA polymerase κ across the genome in human fibroblasts

The paper develops a method to map Pol κ activity across the genome in human fibroblasts and finds it is enriched in euchromatin, gene promoters, and early S-phase replicated DNA.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

This study evaluates the in vivo efficacy of phenylimidazole 296 against C. difficile by targeting CdFabK, showing it retains microbiome stability better than vancomycin and fidaxomicin.

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

Emerging Threat of Ranavirus: Prevalence, Genetic Diversity, and Climatic Drivers of Ranavirus (Family Iridoviridae) in ectothermic vertebrates of Asia

This study investigates ranavirus prevalence, genetic diversity, and climatic drivers in ectothermic vertebrates in southern China, identifying key infection patterns and transmission risks.

LrhA promotes CRISPR-Cas immunity by enhancing primed adaptation in Escherichia coli

This study identifies LrhA as a regulator that enhances CRISPR-Cas immunity in E. coli by promoting adaptation through increased spacer acquisition.

A frog adaptive radiation: Ecomorphological evolution in Old-World shrub frogs (Rhacophoridae: Pseudophilautus)

This study identifies five ecomorphological categories in Pseudophilautus shrub frogs, showing body size and specific traits correlate with habitat type and that ecomorphs evolved multiple times in response to climate changes.

Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants

The paper characterizes BDW568, a non-nucleoside STING agonist, showing it activates STINGA230 variants in human cells and mimics endogenous ligands.

Assembly of tight junction belts by surface condensation and actin elongation

The paper investigates how surface phase transitions control protein condensation to form tight junction belts through ZO-scaffold proteins and actin polymerization.

Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination

This study tracks memory T follicular helper cells and antibody response after three doses of CoronaVac vaccine over 300 days, showing increased neutralizing antibodies and cTFH cells, with correlation between cTFH and antibody titers.

New climatically specialized lineages of Batrachochytrium dendrobatidis and their sub-lethal effects on amphibians establish the Asiatic origins of the pathogen

This study identifies new Bd lineages in China and finds sub-lethal effects on amphibians, supporting Asiatic origins of the pathogen.

Individual Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic Labeling

This paper evaluates Multicolor DiOlistic labeling (MuDi) to reveal detailed morphology of collagenous lamina cribrosa astrocytes in non-human primates and other species.

Early human lung immune cell development and its role in epithelial cell fate

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

The contribution of mutation to variation in temperature-dependent sprint speed in zebrafish, Danio rerio

This study examines how mutations affect temperature-dependent sprint speed in zebrafish, finding that mutational effects are consistently correlated across temperatures, suggesting synergistic cross-environment effects.

Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath Tumors

This study shows that combining SHP2 and autophagy inhibition effectively suppresses NF1-associated MPNSTs in mouse models, suggesting a potential new treatment approach.

Climatic niche evolution of infectious diseases driving amphibian declines

This study shows that amphibian pathogens are intensifying their impact as their climatic niches evolve, with implications for global amphibian declines.

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

Utilising hippocampal neuronal calcium activity in mouse CA1 for a multimodal optical brain-computer interface

This paper develops an optical brain-computer interface using hippocampal calcium activity in mice to decode spatial, visual, and auditory information in real time with high accuracy.

Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli

The paper shows that peptidoglycan maturation regulates the spatiotemporal organization of outer membrane proteins in E. coli by modulating BAM activity and OMP insertion.

Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

The paper studies the evolution of a supergene in white-throated sparrows, finding reduced recombination, low degeneration, and balancing selection maintaining genetic diversity.

Metagenomics revealing molecular profiling of microbial community structure and metabolic capacity in Bamucuo, Tibet

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

WNK kinases sense molecular crowding and rescue cell volume via phase separation

This study shows WNK1 senses molecular crowding by phase separation to activate volume recovery in hypertonic conditions through phosphorylation-dependent signaling.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells

This study shows macroH2A2 promotes dormancy in disseminated cancer cells, preventing metastasis without requiring known dormancy factors.

SpinX: Time-resolved 3D Analysis of Mitotic Spindle Dynamics using Deep Learning Techniques and Mathematical Modelling

SpinX reconstructs gaps in time-lapse microscopy movies using deep learning and mathematical modeling to enable 3D tracking of mitotic spindles with high precision.

Single-cell transcriptome analysis reveals mesenchymal stem cells in cavernous hemangioma

This study identifies mesenchymal stem cells in cavernous hemangioma using scRNA-seq and proposes their origin from epiblast stem cells, along with new cell types and molecular mechanisms involved in tumor formation and immune responses.