Exploration of polyyne biosynthetic gene cluster diversity in bacteria leads to the discovery of the Pseudomonas polyyne protegencin
A. J. Mullins, G. Webster, H. J. Kim, J. Zhao, Y. D. Petrova, C. E. Ramming, M. Jenner, J. A. H. Murray, T. R. Connor, C. Hertweck, G. L. Challis, E. Mahenthiralingam
The paper explores polyyne biosynthetic gene clusters in bacteria, identifies a conserved seven-gene cassette in Pseudomonas, and discovers the metabolite protegencin.
bioRxiv · Mar 5, 2021Microbiology