J. Zhao

Amphetamine in Adolescence Induces a Sex-Specific Mesolimbic Dopamine Phenotype in the Adult Prefrontal Cortex

This study shows that adolescent amphetamine exposure causes sex-specific changes in mesolimbic dopamine axons and PFC dopamine transporter expression in adulthood, with males showing increased vulnerability to drug effects.

Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

This study shows that oxytocin receptor absence in prairie voles impairs peer relationship formation, stability, and reward, with reduced oxytocin release in the nucleus accumbens.

Structure of the minor spliceosomal U11 snRNP

The paper presents a cryo-EM structure of the U11 snRNP complex, revealing its unique architecture and interactions critical for U12-dependent intron recognition.

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds

This study develops a yeast-based bioreporter, DnaSc, for sensitive and cost-effective detection of dioxin-like compounds and AhR agonists with a detection limit of 10 fM for TCDD.

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

Ethylene and ROS Signaling Are Key Regulators of Lateral Root Development under Salt Stress in Tomato

This study identifies genes regulating lateral root development in tomato under salt stress, revealing ethylene and ROS signaling as key factors.

Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

The paper investigates the structural and mechanistic features of mitochondrial creatine kinase (uMtCK) and evaluates the efficacy of a covalent inhibitor in breast cancer cells.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

This study identifies S-HsfA2 in Arabidopsis as a factor that prevents hyperactivation of the heat stress response, balancing heat resistance and growth.

NPD1/GPR37 axis protects painful traumatic brain injury and its complications

This study shows that NPD1/GPR37 signaling protects against TBI-induced neuropathic pain and its complications by modulating demyelination, glial responses, and neuroinflammation.

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

The paper identifies IL-1β as a factor that inhibits SARS-CoV-2-induced cell-cell fusion by promoting actin bundles, thereby restricting viral transmission.

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

A rapid and efficient in vivo inoculation method for introducing tree stem canker pathogens onto leaves: Suitable for large-scale assessment of resistance in poplar breeding progeny

This paper introduces an in vivo leaf inoculation method for assessing poplar resistance to V. sordida, showing it is more efficient and suitable for large-scale screening than traditional stem segment inoculation.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Microbial Response to Natural Disturbances: Rare Biosphere often plays a role

The paper defines rare biosphere and generalists using metagenomic and macroecological metrics, showing their roles in microbial resilience to disturbances like tropical cyclones and warming.

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

The paper develops a biosensor platform to measure GPCR activity in various contexts, revealing insights into coupling selectivity, pharmacogenomics, and signaling bias.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Stimulated Prorocentrum donghaiense cell growth by in-situ mariculture dissolved organic matter

This study shows that in-situ mariculture dissolved organic matter promotes growth and photosynthesis of Prorocentrum donghaiense through absorbtrophy, with bacterioplankton playing helper and competitor roles.

PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

This study identifies PI3Kγ as a regulator of neutrophil extracellular trap formation in abdominal aortic aneurysm via noncanonical pyroptosis, showing its inhibition reduces inflammation and ameliorates AAA.

The N-terminus of Plasmodium falciparum Circumsporozoite Protein Contains Three Non-Overlapping Murine B-cell Epitope Regions

This study identifies three non-overlapping B-cell epitope regions in the N-terminus of Plasmodium falciparum CSP using monoclonal antibodies from immunized mice.

Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

This study shows noncaloric monosaccharides cause excessive angiogenesis in zebrafish by activating foxo1a-marcksl1a signaling, leading to ectopic tip cell formation.

Single-cell RNA sequencing of peripheral blood mononuclear cells reveals complex cellular signalling signatures of metformin treatment type 2 diabetes mellitus

This study uses single-cell RNA sequencing to analyze immune cell signaling in T2DM patients on metformin, identifying key gene correlations and pathways involved in disease mechanisms.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.