Author

M. Jenner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. L. Challis· 4 shared A. J. Mullins· 2 shared E. Mahenthiralingam· 2 shared G. Webster· 2 shared M. Passmore· 2 shared T. R. Connor· 2 shared X. Jian· 2 shared B. P. Tatman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiochemistry

G. L. Challis

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Author profile →

6 papers

Recent·Most cited

Antibiotic skeletal diversification via differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases

X. Jian, F. Pang, C. Hobson, M. Jenner, L. M. Alkhalaf, G. L. Challis

The paper investigates how structural diversity in polyketide antibiotics arises through differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases.

bioRxiv · Nov 30, 2023 · PreprintBiochemistry

Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in trans-acyltransferase polyketide synthases

C. D. Fage, M. Passmore, B. P. Tatman, H. G. Smith, X. Jian, U. C. Dissanayake, G. A. Cisneros, G. L. Challis, J. R. Lewandowski, M. Jenner

The paper solves the structure of an acyl hydrolase (AH) domain and investigates its mechanism for hydrolyzing short-chain thioesters on acyl carrier protein (ACP) domains in trans-AT PKSs.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesis.

M. Jenner, Y. Hai, H. H. Nguyen, M. Passmore, W. Skyrud, J. Kim, N. K. Garg, W. Zhang, R. R. Ogorzalek Loo, Y. Tang

This study characterizes the SidC NRPS involved in fungal siderophore biosynthesis, revealing non-canonical mechanisms in peptidyl siderophore assembly.

bioRxiv · Oct 10, 2022 · PreprintBiochemistry

Exploration of polyyne biosynthetic gene cluster diversity in bacteria leads to the discovery of the Pseudomonas polyyne protegencin

A. J. Mullins, G. Webster, H. J. Kim, J. Zhao, Y. D. Petrova, C. E. Ramming, M. Jenner, J. A. H. Murray, T. R. Connor, C. Hertweck, G. L. Challis, E. Mahenthiralingam

The paper explores polyyne biosynthetic gene clusters in bacteria, identifies a conserved seven-gene cassette in Pseudomonas, and discovers the metabolite protegencin.

bioRxiv · Mar 5, 2021Microbiology

Microarray screening reveals a non-conventional SUMO-binding mode linked to DNA repair by non-homologous end-joining

M. J. Cabello-Lobato, M. Jenner, C. M. Loch, S. P. Jackson, Q. Wu, M. J. Cliff, C. K. Schmidt

The paper identifies non-conventional SUMO2-binding modules on XRCC4 through microarray screening and structural analysis, revealing their role in DNA repair and implications for cancer and gene editing.

bioRxiv · Jan 20, 2021Biochemistry

Kill and cure: genomic phylogeny and bioactivity of a diverse collection of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles

C. Jones, G. Webster, A. J. Mullins, M. Jenner, M. J. Bull, Y. Dashti, T. Spilker, J. Parkhill, T. R. Connor, J. J. LiPuma, G. L. Challis, E. Mahenthiralingam

This study examines the genomic phylogeny and bioactivity of 206 Burkholderia gladioli strains, identifying toxin-producing clades and potential therapeutic strategies for CF-related infections.

bioRxiv · Apr 9, 2020Microbiology