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Microbiology· 3 Immunology· 1

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:organoid / primary culture· 1

Frequent Co-Authors

A.-L. E. Lawrence· 4 shared B. Bons· 4 shared C. E. Wobus· 4 shared D. R. Hill· 4 shared R. P. Berger· 4 shared S. Huang· 4 shared V. K. Yadagiri· 4 shared B. H. Abuaita· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

A.-L. E. Lawrence

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4 papers

Recent·Most cited

Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, J. S. Knight, C. E. Wobus, J. R. Spence, V. B. Young, B. H. Abuaita, M. X. O'Riordan

This study investigates how human neutrophils modulate host responses to two nontyphoidal Salmonella serovars using intestinal organoids and transcriptomics.

bioRxiv · Aug 9, 2022 · PreprintImmunology

Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, G. J. Sule, J. S. Knight, C. E. Wobus, J. Spence, V. Young, M. X. O'Riordan, B. Abuaita

This study shows human neutrophils enhance intestinal epithelial cell extrusion to reduce Salmonella burden during infection, beyond direct antimicrobial activity.

bioRxiv · Mar 25, 2022Microbiology

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids

B. H. Abuaita, A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

bioRxiv · Nov 25, 2020 · PreprintMicrobiology

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system

A.-L. E. Lawrence, B. H. Abuaita, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, C. E. Wobus, J. R. Spence, V. B. Young, M. O'Riordan

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

bioRxiv · Oct 5, 2020Microbiology