Author

J. Spence

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:organoid / primary culture· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Barty· 1 shared A. Glogowska· 1 shared A. Kapoor· 1 shared A. Katz· 1 shared A. Wang· 1 shared A.-L. E. Lawrence· 1 shared B. Abuaita· 1 shared B. Bons· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiophysics

A. Barty

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis

D. Ippolitov, Y.-H. Lin, J. Spence, A. Glogowska, T. Thanasupawat, J. Beiko, M. R. Del Bigio, X. Xu, A. Wang, R. Calvo, A. Kapoor, J. J. Marugan, M. J. Henderson, T. Klonisch, S. Hombach-Klonisch

This study establishes a patient-derived HER2+ brain metastasis model and identifies Poziotinib as an effective RTKi for treating HER2+ breast cancer brain metastasis in mice.

bioRxiv · Feb 19, 2024 · PreprintCancer Biology

Human neutrophils direct epithelial cell extrusion to enhance intestinal epithelial host defense during Salmonella infection

A.-L. E. Lawrence, R. P. Berger, D. R. Hill, S. Huang, V. K. Yadagiri, B. Bons, C. Fields, G. J. Sule, J. S. Knight, C. E. Wobus, J. Spence, V. Young, M. X. O'Riordan, B. Abuaita

This study shows human neutrophils enhance intestinal epithelial cell extrusion to reduce Salmonella burden during infection, beyond direct antimicrobial activity.

bioRxiv · Mar 25, 2022Microbiology

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

J. Olmos, S. Pandey, J. M. Martin-Garcia, G. Calvey, A. Katz, J. Knoska, C. Kupitz, M. S. Hunter, M. Liang, D. Oberthuer, O. Yefanov, M. Wiedorn, M. Heymann, M. Holl, K. Pande, , Our

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

bioRxiv · Jan 18, 2018Biophysics