J. R. Spence

This paper develops AORBs, a high-throughput human airway organoid system, to robustly assess antiviral efficacy against SARS-CoV-2 with high throughput and clinical relevance.

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

This study identifies TGFB1 as a key driver of fetal reprogramming and intestinal regeneration, showing its role in enhancing epithelial repair through a YAP-SOX9 transcriptional circuit.

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

This study investigates how human neutrophils modulate host responses to two nontyphoidal Salmonella serovars using intestinal organoids and transcriptomics.

This study develops an in vitro protocol to generate mature human intestinal epithelium from pluripotent stem cells using NRG1 and single-cell transcriptomics.

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.

This study shows vertical sleeve gastrectomy increases enteroendocrine cells via FXR activation in intestinal stem cells, using RNAseq and organoid experiments.

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

This study shows that E. coli lacking RpoS has reduced colonization ability in human intestinal organoids but not in germ-free mice, indicating different stress environments in these models.

This study examines how calcium levels affect colonoid tissue barrier function and cohesion, finding that low calcium supports permeability barriers while higher levels enhance tissue cohesion.

This study shows that human lung organoids mature into airway-like structures when cultured on specific biomaterial scaffolds, with properties like pore interconnectivity and degradation rate influencing maturation and structure.

The paper isolates and characterizes LGR5-positive cells from human colon adenomas using organoids and RNA-sequencing, identifying correlations with CRC-specific genes.