SURF2 is a MDM2 antagonist in triggering the nucleolar stress response
S. Tagneres, P. Espirito-Santo, J. Radermecker, D. Rinaldi, C. Froment, Q. Provost, S. Capeille, N. J. Watkins, J. Marcoux, P.-E. Gleizes, V. Marcel, C. Plisson-Chastang, S. LEBARON
The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.
bioRxiv · Jan 9, 2024Cell Biology