Author

C. Garcia-Doval

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Berk· 2 shared F. Schwede· 2 shared J. Hall· 2 shared J. T. Rostol· 2 shared M. Jinek· 2 shared O. Niewoehner· 2 shared D. Mayo-Munoz· 1 shared H. G. Hampton· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

C. Berk

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection

D. Mayo-Munoz, L. M. Smith, C. Garcia-Doval, L. M. Malone, K. R. Harding, S. A. Jackson, H. G. Hampton, R. D. Fagerlund, L. F. Gumy, P. C. Fineran

The paper shows type III CRISPR-Cas systems provide immunity against jumbo phages by degrading bacterial DNA and disrupting phage replication through an accessory nuclease, leading to abortive infection.

bioRxiv · Jun 20, 2022Microbiology

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

C. Garcia-Doval, F. Schwede, C. Berk, J. T. Rostol, O. Niewoehner, O. Tejero, J. Hall, L. A. Marraffini, M. Jinek

This study investigates how EiCsm6 degrades its activator cA6 and uses structural and functional analyses to reveal activation and self-inactivation mechanisms of the CRISPR ribonuclease.

bioRxiv · Feb 19, 2020Biochemistry

Type III CRISPR-Cas systems generate cyclic oligoadenylate second messengers to activate Csm6 RNases

O. Niewoehner, C. Garcia-Doval, J. T. Rostol, C. Berk, F. Schwede, L. Bigler, J. Hall, L. Marraffini, M. Jinek

bioRxiv · Jun 23, 2017Biochemistry