Author

F. Schwede

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Approach:biophysical modeling· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. Berk· 2 shared C. Garcia-Doval· 2 shared J. Hall· 2 shared J. T. Rostol· 2 shared M. Jinek· 2 shared O. Niewoehner· 2 shared A. Rentsch· 1 shared B. R. Morehouse· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

C. Berk

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

V. Ober, G. B. Githure, Y. Volpato Santos, S. Becker, G. Moya, J. Basquin, F. Schwede, E. Lorentzen, M. Boshart

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.

bioRxiv · Oct 24, 2023Biochemistry

cGLRs are a diverse family of pattern recognition receptors in animal innate immunity

Y. Li, K. M. Slavik, B. R. Morehouse, C. C. d. O. Mann, K. Mears, J. Liu, D. Kashin, F. Schwede, P. J. Kranzusch

The paper identifies cGLRs as a widespread family of pattern recognition receptors in animal innate immunity and elucidates their conserved signaling mechanisms.

bioRxiv · Feb 22, 2023Biochemistry

Using cGMP analogues to modulate photoreceptor light sensitivity: Perspectives for the treatment of retinal degeneration.

S. Wucherpfennig, W. Haq, V. Popp, S. Kesh, S. Das, C. Melle, A. Rentsch, F. Schwede, F. Paquet-Durand, V. Nache

The paper presents a strategy using cGMP analogues to selectively modulate rod or cone photoreceptor function in retinal degeneration, preserving normal CNG-channel function.

bioRxiv · Feb 7, 2022 · PreprintPhysiology

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

C. Garcia-Doval, F. Schwede, C. Berk, J. T. Rostol, O. Niewoehner, O. Tejero, J. Hall, L. A. Marraffini, M. Jinek

This study investigates how EiCsm6 degrades its activator cA6 and uses structural and functional analyses to reveal activation and self-inactivation mechanisms of the CRISPR ribonuclease.

bioRxiv · Feb 19, 2020Biochemistry

Type III CRISPR-Cas systems generate cyclic oligoadenylate second messengers to activate Csm6 RNases

O. Niewoehner, C. Garcia-Doval, J. T. Rostol, C. Berk, F. Schwede, L. Bigler, J. Hall, L. Marraffini, M. Jinek

bioRxiv · Jun 23, 2017Biochemistry