L. M. Smith

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

This study uses PET imaging to assess NRF2 activation in NSCLC, showing [18F]FSPG as a marker of therapeutic resistance and a potential target for treatment.

The Chicken Chorioallantoic Membrane as a Low-Cost, High-Throughput Model for Cancer Imaging

This paper evaluates the chicken chorioallantoic membrane as a low-cost, high-throughput alternative to mouse models for cancer imaging using PET/CT.

An evolutionary epigenetic clock in plants

This paper introduces an epigenetic clock based on stochastic DNA methylation changes in plants, enabling high-resolution temporal analysis of phylogenetic relationships.

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.

Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection

The paper shows type III CRISPR-Cas systems provide immunity against jumbo phages by degrading bacterial DNA and disrupting phage replication through an accessory nuclease, leading to abortive infection.

A novel triple-action inhibitor targeting B-cell receptor signaling and BRD4 demonstrates preclinical activity in chronic lymphocytic leukemia

This study shows that SRX3305, a triple-action inhibitor targeting BTK, PI3K, and BRD4, reduces CLL cell proliferation, promotes apoptosis, and blocks migration in preclinical models.

Population dynamics of free-roaming dogs in Europe and implications for population control

This study quantifies free-roaming dog population dynamics in Europe, finding lower survival and higher entry rates in Lviv compared to Pescara, and highlights the role of movement between subpopulations in recruitment.

Assessing the impact of free-roaming dog population management through systems modelling

This study uses a systems model to evaluate dog population management strategies, finding that combining fertility control with responsible ownership interventions is most effective for long-term population reduction and welfare improvement.

Rice leaves undergo a rapid metabolic reconfiguration during a specific stage of primordium development

The paper identifies a metabolic shift in rice leaves during a specific developmental stage that marks the transition to photosynthetic competency.

Multi-Factor Authentication of Potential 5' Splice Sites by the Saccharomyces cerevisiae U1 snRNP

This study uses CoSMoS to show that yeast U1 snRNP reversibly selects 5' splice sites through a sequence-dependent, two-step mechanism involving kinetic selection.

Public attitudes towards free-roaming dogs and dog ownership practices in Bulgaria, Italy, and Ukraine

This study examines public attitudes and dog ownership practices in Bulgaria, Italy, and Ukraine to inform effective dog population management strategies.

In vivo magnetic resonance spectroscopy of hyperpolarized pyruvate in a male guinea pig model of life-long Western diet consumption and non-alcoholic fatty liver disease development

This study uses hyperpolarized MRS and MRI to examine how a lifelong Western diet affects liver metabolism and NAFLD in guinea pigs, finding increased fat deposition and shifts in metabolic pathways.

Can we put Humpty Dumpty back together again? What does protein quantification mean in bottom-up proteomics?

The paper questions the assumption that all peptides from a protein coding gene represent the same protein quantity in bottom-up proteomics, highlighting the need for better methods to account for proteomic complexity.

Identifying HIV-1 RNA splice variant protein interactomes using HyPR-MSSV

This study identifies protein interactomes of HIV-1 RNA splice variants using HyPR-MSSV, revealing 212 differentially associated proteins and their roles in viral replication.

Interspecies Social Spreading: Interaction between two sessile soil bacteria leads to emergence of surface motility

This paper studies the interaction between two soil bacteria, showing that their co-culture on hard agar leads to an emergent surface motility behavior called interspecies social spreading.