Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection
D. Mayo-Munoz, L. M. Smith, C. Garcia-Doval…·P. C. Fineran
The paper shows type III CRISPR-Cas systems provide immunity against jumbo phages by degrading bacterial DNA and disrupting phage replication through an accessory nuclease, leading to abortive infection.