Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM
O. Llorca, A. Lopez-Perrote, N. Hug, A. Gonzalez-Corpas, C. F. Rodriguez, M. Serna, C. Garcia-Martin, J. Boskovic, R. Fernandez-Leiro, J. F. Caceres
The paper shows DHX34 interacts with RUVBL1-RUVBL2 and alters its conformation to reduce ATP hydrolysis, linking it to NMD activation.
bioRxiv · Sep 28, 2020Biophysics