N. Hug

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

The paper shows DHX34 interacts with RUVBL1-RUVBL2 and alters its conformation to reduce ATP hydrolysis, linking it to NMD activation.

Genetic variation and RNA structure regulate microRNA biogenesis

The paper shows a genetic variant in pri-mir-30c-1 alters RNA structure, enhancing SRSF3 binding and increasing miR-30c levels in vitro and in cells.