NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
L. Van Haute, S.-Y. Lee, B. J. McCann, C. A. Powell, D. Bansal, C. Garone, S. Shin, J.-S. Kim, M. Frye, J. G. Gleeson, E. A. Miska, H.-W. Rhee, M. Minczuk
This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.
bioRxiv · May 3, 2019Biochemistry