S.-Y. Lee

Connexin43 in mesenchymal lineage cells regulates body adiposity and energy metabolism in mice

This study shows that Cx43 in mesenchymal lineage cells reduces body adiposity and improves metabolic health in mice on a high-fat diet.

E protein control of NKgammadeltaT cell development through both generation and function of the stereotypic Vgamma1Vdelta6.3 TCR

This study shows that Id3 deficiency affects the development of gamma delta T cell subsets by regulating the generation and function of the Vgamma1Vdelta6.3 TCR.

Spatial dissection of cellular heterogeneity and functional crosstalk in the tumor microenvironments of gastric cancers

This study uses spatial transcriptomics to analyze gastric cancer tumor microenvironments, identifying subtypes and functional interactions between cell types that correlate with clinical outcomes.

Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae

The paper presents the cryo-EM structure of the FtsEX-EnvC complex from V. cholerae and shows how EnvC's conformational changes regulate amidase activity for septal peptidoglycan hydrolysis.

Enhanced Omicron subvariant cross-neutralization efficacy of a monovalent SARS-CoV-2 BA.4/5 mRNA vaccine encoding a noncleaved, nonfusogenic spike antigen

This study develops a modified SARS-CoV-2 spike antigen that enhances cross-neutralization against Omicron subvariants, despite reduced neutralizing potency.

Structural insights into TRPV4-Rho GTPase signaling complex function and disease

The paper presents cryo-EM structures of TRPV4-RhoA complexes in different states, revealing how their interaction regulates TRPV4 function and contributes to neuromuscular disease.

Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2

The paper presents cryo-EM structures of OCT1 and OCT2 in different states and combines them with functional experiments to reveal principles of organic cation recognition and the alternating access mechanism.

Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction

This study shows that partial in vivo reprogramming using OSKM factors induces intestinal regeneration via Ptgs1-driven prostaglandin synthesis, distinct from normal Ptgs2-dependent regeneration.

Peroxiredoxin 5 regulates osteogenic differentiation via interaction with hnRNPK during bone regeneration

This study identifies Prdx5's role in bone regeneration by regulating osteoblast differentiation through interaction with hnRNPK, impacting osteocalcin expression and osteoclast activity.

The evolutionary trajectory of drosophilid walking

This study analyzes the evolution of walking in drosophilid species, finding that movement patterns are conserved in a universal behavior space but evolve rapidly in their temporal structure.

The in vitro and in vivo potency of CT-P59 against Delta and its associated variants of SARS-CoV-2

This study evaluates CT-P59's antiviral activity against Delta and its variants, showing reduced in vitro potency but effective in vivo neutralization and symptom remission in mice.

Therapeutic efficacy of CT-P59 against P.1 variant of SARS-CoV-2

This study evaluates CT-P59's efficacy against the P.1 SARS-CoV-2 variant through in vitro and in vivo tests, showing reduced in vitro neutralization but therapeutic benefit in mice.

High-dose drug heat map based on organoid array chip for drug selection with high safety and efficacy

The paper develops an organoid array chip to test drug safety and efficacy using high-dose drug heat maps, identifying four compounds with high efficacy and low toxicity against GBM cells.

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant

This study evaluates CT-P59's efficacy against SARS-CoV-2 variants, showing reduced in vitro neutralization but effective in vivo therapeutic potential against the B.1.351 variant.

Characteristics of viable but nonculturable Vibrio parahaemolyticus induced under extended periods of cold-starvation with various NaCl concentrations

This study investigates the characteristics of Vibrio parahaemolyticus in the viable but nonculturable state under cold-starvation with varying NaCl concentrations, showing changes in cytotoxicity, fatty acid composition, and membrane potential.

Differential risk of incident cancer in patients with heart failure: A nationwide population-based cohort study

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.

Visualizing Conformational Transitions of the Lipid II Flippase MurJ

This study reports crystal structures of MurJ in different conformations to elucidate its mechanism of lipid flipping and identify a key ion for function.

Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

This study uses cryo-EM to show that RTx induces two-fold symmetric conformations of TRPV2, with greater symmetry in nanodiscs than in amphipol.

Sarcopenia is an independent predictor of hospitalization in chronic kidney disease outpatients

This study finds that sarcopenia and presarcopenia predict higher hospitalization risk in CKD outpatients, using ASM/wt and handgrip strength as markers.

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

This study reports cryo-EM structures of TRPM2 channel in intermediate states to elucidate structural transitions during ligand-dependent gating.

Conformational ensemble of the human TRPV3 ion channel

The paper presents cryo-EM structures of human TRPV3 in different states to elucidate its sensitization and gating mechanisms.