Author

M. Frye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

S. Delaunay· 3 shared A. Heit-Mondrzyk· 2 shared D. Sohn· 2 shared D. T. Odom· 2 shared R. E. Wagner· 2 shared A. A. Khawaja· 1 shared A. Bakr· 1 shared A. Balmes· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

S. Delaunay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

C. Pauli, M. Kienhoefer, M. Blank, O. Begik, C. Rohde, D. Heid, F. Xu, S. M. N. Zimmermann, K. Weidenauer, S. Delaunay, N. Krall, K. Trunk, D. Zhao, F. Zhou, A. Heit-Mondrzyk, , M. Frye

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.

bioRxiv · Jul 13, 2024 · PreprintCell Biology

SRSF2 transcriptional function maintains genome integrity during cell division

R. E. Wagner, L. Arnetzl, T. Britto-Borges, A. Heit-Mondrzyk, A. Bakr, E. Sollier, J. Panten, S. Delaunay, D. Sohn, P. Schmezer, D. T. Odom, K. Mueller-Decker, C. Plass, C. Dieterich, P. Lutsik, , M. Frye

This study shows that SRSF2 mutations cause DNA damage and cell cycle arrest, highlighting its role in transcription regulation during cell division.

bioRxiv · Jul 8, 2024Cell Biology

Regenerative cell turnover coupled to a tumor-hostile niche protects naked mole-rats from cancer

M. Behm, P. Baeza-Centurion, S. Weser, V. F. Busa, P. Zafferani, L. Penso-Dolfin, F. J. Botey, S. Delaunay, N. Hirschmuller, B. Berthet, M.-L. Koch, S. Del Prete, M. Bekavac, D. Sohn, L. Penteskoufi, , M. Frye

This study identifies a tumor-suppressive strategy in naked mole-rats that couples regenerative cell turnover with a tumor-hostile stromal niche to prevent cancer.

bioRxiv · Oct 10, 2023 · PreprintCancer Biology

Role of the NO-GC/cGMP signaling pathway in platelet biomechanics

J. G. Rodriguez, A. Balmes, J. Seifert, D. Pinto-Quintero, A. A. Khawaja, M. Boffito, M. Frye, A. Friebe, M. Emerson, F. Seta, R. Feil, S. Feil, T. E. Schaffer

This study investigates the NO-GC/cGMP pathway's role in platelet biomechanics, showing that stimulators reduce cellular stiffness and activation.

bioRxiv · Apr 28, 2023 · PreprintBiochemistry

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

L. Van Haute, S.-Y. Lee, B. J. McCann, C. A. Powell, D. Bansal, C. Garone, S. Shin, J.-S. Kim, M. Frye, J. G. Gleeson, E. A. Miska, H.-W. Rhee, M. Minczuk

This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.

bioRxiv · May 3, 2019Biochemistry