Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
M. Zafferani, C. Haddad, L. Luo, J. Davila-Calderon, L. Yuan-Chiu, C. Shema Mugisha, A. G. Monaghan, A. A. Kennedy, J. D. Yesselman, R. R. Gifford, A. W. Tai, S. B. Kutluay, M.-L. Li, G. Brewer, B. S. Tolbert, A. E. Hargrove
This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.
bioRxiv · Dec 5, 2020Microbiology