L. Luo

The evolution of autonomy from two cooperative specialists in fluctuating environments

This study shows that autonomous genotypes can evolve from cooperative microbial specialists in fluctuating environments through horizontal gene transfer.

Colicin Receptor CirA Enhances Salmonella Typhimuriums Resistance to Colicin Ib in the Absence of the Cognate Immunity Protein

This study identifies CirA as a colicin receptor that enhances resistance to ColIb in S. Typhimurium despite lacking the immunity protein.

Molecular Signatures for Microbe-Associated Colorectal Cancers

The paper identifies a Microbe-Associated Colorectal Cancer Signature (MACS) induced by Fusobacterium nucleatum in genetically predisposed hosts, linking microbial infection to early CRC initiation.

Interaction between ciliary component proteins from Chlamydomonas revealed by CRISPR/CAS9, cryo-electron tomography and mass spectrometry

The paper investigates protein interactions in cilia using CRISPR/CAS9, cryo-ET, and mass spectrometry, revealing a complex involving FAP263, FAP78, FAP184, and FAP151, and links it to dynein f phosphorylation.

Diversification of an emerging bacterial plant pathogen; insights from the global spread of Xanthomonas euvesicatoria pv. perforans

This study analyzes the global genetic diversity and evolution of Xanthomonas euvesicatoria pv. perforans, revealing population structure and effector gene variation linked to its spread as a tomato pathogen.

High immigration rates critical for establishing emigration-driven diversity in microbial communities

The paper investigates how microbial dispersal affects community diversity under competition, finding that high immigration rates enhance diversity through emigration.

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Loss of function of Atrx leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma

This study shows that loss of Atrx in a mouse sarcoma model activates the ALT telomere maintenance pathway independently of telomerase, leading to telomere instability and APB formation.

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo

This paper introduces a wearable bioelectronic bandage that delivers fluoxetine on-demand to wounds, reducing inflammation and accelerating healing in mice.

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

This study identifies a phospho-regulated interaction between Dyn1xA and Endophilin A1 via a unique C-terminal extension, essential for ultrafast endocytosis.

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

Atrx deletion impairs cGAS-STING signaling and increases response to radiation and oncolytic herpesvirus in sarcoma

This study shows that ATRX deletion in sarcomas increases sensitivity to radiation and oncolytic herpesvirus by impairing cGAS-STING signaling and reducing immune response.

56Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice

This study shows that 56Fe ion exposure increases lung and brain tumor incidence similarly in male and female mice, with 56Fe ions causing faster tumor development than X-rays.

p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

Toleration of Frameshift Mutations in mRNA Sequences Encoding the N-terminal Peptides of Bacterial Type III Effectors

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

Both CD8 and CD4 T cells contribute to immunosurveillance preventing the development of neoantigen-expressing autochthonous sarcomas

This study develops an autochthonous murine sarcoma model and shows that both CD8 and CD4 T cells are required for immunosurveillance against neoantigen-expressing tumors.

DNA nanopores as artificial membrane channels for origami based bioelectronics

The paper develops DNA nanopores integrated with bioprotonic contacts to create efficient artificial ion-channel interfaces for bioelectronic signal readout.

p53 and RB Cooperate to Suppress Transposable Elements

This study shows that loss of p53 and RB in mouse cells leads to epigenetic changes and upregulation of transposable elements, suggesting they work together to suppress transposons and prevent tumorigenesis.

Establishment of primary renal lymphoma model and the clinical relevance

The paper establishes a novel MA-K cell line that models primary renal lymphoma and identifies biomarkers predictive of clinical outcomes in DLBCL.

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

Impact of various vaccine boosters on neutralization against Omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

Lactococcus lactis sb. cremoris orchestrates signal events in the gut epithelium via TLR2 to promote tissue restitution

This study shows that Lactococcus lactis subsp. cremoris promotes gut tissue repair via TLR2 signaling, enhancing epithelial migration and cytoprotection.

Direct regulation of cell cycle regulatory gene expression by NtrX to promote Sinorhizobium meliloti cell division

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.