S. B. Kutluay

This study identifies calpain-2 as a host factor facilitating SARS-CoV-2 entry and shows calpain inhibitors inhibit viral infection through an Mpro-independent pathway.

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

This study identifies CARD8 as a sensor of HIV-1 protease activity, triggering pyroptosis of infected cells and clearing latent HIV-1 in CD4+ T cells.

This paper develops a Q-RT-PCR assay to monitor SARS-CoV-2 growth in cell culture without RNA extraction, showing it can identify inhibitors of viral replication.

This study identifies three mechanisms by which class II HIV-1 integrase substitutions disrupt IN-RNA interactions, leading to virion maturation defects and premature viral genome degradation.