Pharmacology & ToxicologybioRxiv
Targeting cancer with small molecule pan-KRAS degraders
J. Popow, W. Farnaby, A. Gollner…·A. Ciulli
A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.
DOI 10.1126/science.adm8684