Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal
M. Pearson, C. Haslam, A. Fosberry, E. J. Jones, M. Reglinski, R. J. Edwards, R. A. Lawrenson, J. C. Brown, D. Mossakowska, J. E. Pease, S. Sriskandan
This study investigates SpyCEP's enzymatic function, revealing the C-terminal's role in substrate binding and the N-terminal's necessity for full catalytic activity.
bioRxiv · Nov 14, 2021 · PreprintMicrobiology