R. J. Edwards

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

This study shows non-neutralizing SARS-CoV-2 antibodies protect mice from severe disease via Fc-mediated effector functions, reducing viral load and lung damage.

This study uses time-resolved scattering to observe microsecond dynamics in HIV-1 Env, revealing rapid transitions that conventional strategies may not address.

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

This study compares SNP and SV genetic diversity across invasive European starling populations, finding discrepancies in diversity patterns and evidence of balancing selection differences between SNP and SV classes.

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

This study investigates how B cells distinguish HIV-1 Env proteins based on binding kinetics rather than equilibrium dissociation constants.

This study investigates SpyCEP's enzymatic function, revealing the C-terminal's role in substrate binding and the N-terminal's necessity for full catalytic activity.

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

The paper examines horizontal transposon transfer in Hydrophiinae snakes to infer their ancestral ecological route from Asia to Australia.

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

This study examines how mutations in SARS-CoV-2 spike protein affect its structure, conformation, and antigenicity across variants from different origins.

This study shows that SARS-CoV-2 vaccines induce neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, and batCoVs in monkeys.

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

This study shows the D614G mutation in SARS-CoV-2 spike protein increases furin cleavage efficiency and alters RBD dynamics through allosteric effects.

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

The paper shows glycans on SARS-CoV-2 Spike influence RBD conformational states, affecting antibody neutralization and vaccine design.

The paper analyzes SARS-CoV-2 spike protein conformations and develops engineered constructs to control its mobility for vaccine design.

The paper identifies four exocytic fusion modes in developing neurons and shows TRIM67 promotes FVF-like exocytosis by limiting SNAP47 incorporation into SNARE complexes.