Mechanistic Elucidation of the Antitumor Properties of a Novel Death Receptor 5 Activator
M. Wang, M. Law, B. Davis, E. Yaaghubi, A. Franceschini Ghilardi, R. Ferreira, C.-W. Chiang, O. Guryanova, D. Kopinke, C. Heldermon, R. Castellano, B. Law
This study identifies DDAs as compounds that upregulate DR5 in cancer cells, leading to apoptosis and synergy with TRAIL, with selectivity for oncogene-transformed cells.
bioRxiv · Jul 14, 2019 · PreprintCancer Biology