B. Davis

Convolvulaceae of Guinea: taxonomy, conservation and useful plants

This paper provides a taxonomic treatment of the Convolvulaceae family in Guinea, documenting species, their uses, and preliminary conservation assessments.

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.

This study shows IL1β promotes myeloid expansion and self-renewal in TET2-deficient hematopoietic stem/progenitor cells, leading to a premalignant phenotype that can be suppressed by IL1R1 inhibition.

mRNA-based vaccines against SARS-CoV-2 do not stimulate interferon stimulatory gene expression in individuals affected by Aicardi Goutieres Syndrome.

This study investigates whether mRNA-based SARS-CoV-2 vaccines induce interferon responses in individuals with Aicardi Goutieres Syndrome (AGS) and finds no significant increase in interferon signatures.

The N-terminal Tail of C. elegans CENP-A Interacts with KNL-2 and is Essential for Centromeric Chromatin Assembly

This study identifies the N-terminal tail of C. elegans CENP-A as essential for centromeric chromatin assembly through its interaction with KNL-2, compensating for the absence of Scm3/HJURP.

Multiplexed experimental strategies for fragment library screening using SPR biosensors

The paper presents multiplexed SPR biosensor strategies for fragment library screening, improving hit identification for challenging targets.

Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome

This study investigates the role of the lineage-specific LAVA retrotransposon in gibbon gene regulation, finding it overlaps with enhancer chromatin states and is associated with gene expression and selection.

Extracellular ATP released from Candida albicans activates non-peptidergic neurons to augment host defense

This study shows that ATP released by Candida albicans activates non-peptidergic neurons to enhance anti-Candida immune responses.

Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments

This paper classifies chemical exchange regimes in 2D NMR spectra and introduces optimized experiments for improved analysis of molecular interactions.

Mechanistic Elucidation of the Antitumor Properties of a Novel Death Receptor 5 Activator

This study identifies DDAs as compounds that upregulate DR5 in cancer cells, leading to apoptosis and synergy with TRAIL, with selectivity for oncogene-transformed cells.

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia

The paper identifies mutation synergy between CSF3R and CEBPA in AML, showing their interaction at myeloid lineage enhancers and the requirement of CEBPA mutations as an initial event.

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine melanoma by integrated comparative genomic analysis

This study identifies somatic PTPRJ mutations and dysregulated pathways in canine melanoma through genomic analysis, revealing similarities with human melanoma subtypes and potential therapeutic targets.