Author

C. J. Markin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:protein structure prediction· 1 Organism:yeast· 1

Frequent Co-Authors

D. A. Mokhtari· 3 shared P. M. Fordyce· 3 shared D. Herschlag· 2 shared F. Sunden· 2 shared A. K. Aditham· 1 shared C. Sabatti· 1 shared E. Akiva· 1 shared M. J. Appel· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

D. A. Mokhtari

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3 papers

Recent·Most cited

High-throughput enzymology reveals mutations throughout a phosphatase that decouple catalysis and transition state analog affinity

C. J. Markin, D. A. Mokhtari, S. Du, T. Doukov, F. Sunden, P. M. Fordyce, D. Herschlag

This study uses HT-MEK to analyze 1,004 PafA mutants, showing that distal mutations affect catalysis more than TSA binding, suggesting conformational changes influence enzyme function.

bioRxiv · Nov 7, 2022 · PreprintBiochemistry

Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics

C. J. Markin, D. A. Mokhtari, F. Sunden, M. J. Appel, E. Akiva, S. Longwell, C. Sabatti, D. Herschlag, P. M. Fordyce

HT-MEK, a microfluidic platform, reveals enzyme architectures shaping function through high-throughput kinetic analysis of enzyme variants.

bioRxiv · Nov 24, 2020Biochemistry

High-throughput binding affinity measurements for mutations spanning a transcription factor-DNA interface reveal affinity and specificity determinants

A. K. Aditham, C. J. Markin, D. A. Mokhtari, N. V. DelRosso, P. M. Fordyce

The paper measures binding affinities of TF mutants and DNA variants to identify affinity and specificity determinants in the TF-DNA interface.

bioRxiv · Jun 22, 2020Biophysics