Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium
H. T. Lindholm, N. Parmar, C. L. Drurey, J. L. Ostrop, A. Diez-Sanchez, R. Maizels, M. J. Oudhoff
The paper investigates how cytokines regulate intestinal epithelial responses through developmental pathways, showing IL-13 induces goblet cells via NOTCH signaling and uses BMP signaling as a feedback loop in tuft cell hyperplasia.
bioRxiv · Jun 19, 2020Immunology