M. J. Oudhoff

Postnatal intestinal epithelial maturation by LSD1 controls the small intestinal immune cell composition independently from the microbiota

This study shows that LSD1 in intestinal epithelial cells controls immune cell composition postnatally, independent of microbiota.

Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection

This study shows that Mmp17-deficient mice have increased goblet cell effector genes and resistance to Trichuris muris infection without changes in traditional immune modulators.

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation

This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.

Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

The paper investigates how cytokines regulate intestinal epithelial responses through developmental pathways, showing IL-13 induces goblet cells via NOTCH signaling and uses BMP signaling as a feedback loop in tuft cell hyperplasia.

Smooth muscle-specific MMP17 (MT4-MMP) defines the intestinal ECM niche

The paper identifies MMP17 as a smooth muscle-specific factor critical for intestinal epithelial repair and stem cell niche regulation through its cleavage of PERIOSTIN and activation of YAP.